European protocols for the diagnosis and initial treatment of interstitial lung disease in children.
Identifieur interne : 000E88 ( Main/Exploration ); précédent : 000E87; suivant : 000E89European protocols for the diagnosis and initial treatment of interstitial lung disease in children.
Auteurs : Andrew Bush [Royaume-Uni] ; Steve Cunningham [Royaume-Uni] ; Jacques De Blic [France] ; Angelo Barbato [Italie] ; Annick Clement [France] ; Ralph Epaud [France] ; Meike Hengst [Allemagne] ; Nural Kiper [Turquie] ; Andrew G. Nicholson [Royaume-Uni] ; Martin Wetzke [Allemagne] ; Deborah Snijders [Italie] ; Nicolaus Schwerk [Allemagne] ; Matthias Griese [Allemagne]Source :
- Thorax [ 1468-3296 ] ; 2015.
Descripteurs français
- KwdFr :
- Bronchoscopie (), Diagnostic différentiel, Enfant, Europe (épidémiologie), Humains, Lavage bronchoalvéolaire (), Morbidité, Pneumopathies interstitielles (), Pneumopathies interstitielles (diagnostic), Pneumopathies interstitielles (épidémiologie), Prise en charge de la maladie, Protocoles cliniques, Tomodensitométrie ().
- MESH :
English descriptors
- KwdEn :
- Bronchoalveolar Lavage (methods), Bronchoscopy (methods), Child, Clinical Protocols, Diagnosis, Differential, Disease Management, Europe (epidemiology), Humans, Lung Diseases, Interstitial (diagnosis), Lung Diseases, Interstitial (epidemiology), Lung Diseases, Interstitial (therapy), Morbidity, Tomography, X-Ray Computed (methods).
- MESH :
- geographic , epidemiology : Europe.
- diagnosis : Lung Diseases, Interstitial.
- epidemiology : Lung Diseases, Interstitial.
- methods : Bronchoalveolar Lavage, Bronchoscopy, Tomography, X-Ray Computed.
- therapy : Lung Diseases, Interstitial.
- Child, Clinical Protocols, Diagnosis, Differential, Disease Management, Humans, Morbidity.
Abstract
Interstitial lung disease in children (chILD) is rare, and most centres will only see a few cases/year. There are numerous possible underlying diagnoses, with specific and non-specific treatment possibilities. The chILD-EU collaboration has brought together centres from across Europe to advance understanding of these considerations, and as part of this process, has created standard operating procedures and protocols for the investigation of chILD. Where established consensus documents exist already, for example, for the performance of bronchoalveolar lavage and processing of lung biopsies, these have been adopted. This manuscript reports our proposals for a staged investigation of chILD, starting from when the condition is suspected to defining the diagnosis, using pathways dependent on the clinical condition and the degree of illness of the child. These include the performance of genetic testing, echocardiography, high-resolution CT, bronchoscopy when appropriate and the definitive investigation of lung biopsy, in order to establish a precise diagnosis. Since no randomised controlled trials of treatment have ever been performed, we also report a Delphi consensus process to try to harmonise treatment protocols such as the use of intravenous and oral corticosteroids, and add-on therapies such as hydroxychloroquine and azithromycin. The aim is not to dictate to clinicians when a therapeutic trial should be performed, but to offer the possibility to collaborators of having a unified approach when a decision to treat has been made.
DOI: 10.1136/thoraxjnl-2015-207349
PubMed: 26135832
Affiliations:
- Allemagne, France, Italie, Royaume-Uni, Turquie
- Angleterre, Basse-Saxe, Bavière, District de Haute-Bavière, Grand Londres, Écosse, Île-de-France
- Créteil, Hanovre, Londres, Munich, Paris, Édimbourg
- Université d'Édimbourg
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Le document en format XML
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sort="Cunningham, Steve" uniqKey="Cunningham S" first="Steve" last="Cunningham">Steve Cunningham</name><affiliation wicri:level="4"><nlm:affiliation>NHS Lothian and University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Lothian and University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="De Blic, Jacques" sort="De Blic, Jacques" uniqKey="De Blic J" first="Jacques" last="De Blic">Jacques De Blic</name><affiliation wicri:level="3"><nlm:affiliation>Pediatric Pulmonary Department, Hôpital Universitaire Necker Enfants Malades, Paris, France Université Paris Descartes, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pediatric Pulmonary Department, Hôpital Universitaire Necker Enfants Malades, Paris, France Université Paris Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Barbato, Angelo" sort="Barbato, Angelo" uniqKey="Barbato A" first="Angelo" last="Barbato">Angelo Barbato</name><affiliation wicri:level="1"><nlm:affiliation>Department of Women's and Children's Health, University of Padova, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Women's and Children's Health, University of Padova, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Clement, Annick" sort="Clement, Annick" uniqKey="Clement A" first="Annick" last="Clement">Annick Clement</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Armand-Trousseau, Pneumologie pédiatrique, Centre National de Référence des Maladies Respiratoires Rares, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Armand-Trousseau, Pneumologie pédiatrique, Centre National de Référence des Maladies Respiratoires Rares, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Epaud, Ralph" sort="Epaud, Ralph" uniqKey="Epaud R" first="Ralph" last="Epaud">Ralph Epaud</name><affiliation wicri:level="3"><nlm:affiliation>Faculté de Médecine, Centre Intercommunal de Créteil, Service de Pédiatrie, INSERM, U955, Université Paris-Est, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine, Centre Intercommunal de Créteil, Service de Pédiatrie, INSERM, U955, Université Paris-Est, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Hengst, Meike" sort="Hengst, Meike" uniqKey="Hengst M" first="Meike" last="Hengst">Meike Hengst</name><affiliation wicri:level="3"><nlm:affiliation>Children's Hospital of Ludwig, Maximilians University, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Children's Hospital of Ludwig, Maximilians University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Kiper, Nural" sort="Kiper, Nural" uniqKey="Kiper N" first="Nural" last="Kiper">Nural Kiper</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Department of Pediatric Pulmonology, Hacettepe University, Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Faculty of Medicine, Department of Pediatric Pulmonology, Hacettepe University, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Nicholson, Andrew G" sort="Nicholson, Andrew G" uniqKey="Nicholson A" first="Andrew G" last="Nicholson">Andrew G. Nicholson</name><affiliation wicri:level="3"><nlm:affiliation>Imperial College & Royal Brompton Harefield NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College & Royal Brompton Harefield NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Wetzke, Martin" sort="Wetzke, Martin" uniqKey="Wetzke M" first="Martin" last="Wetzke">Martin Wetzke</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatrics, Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics, Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Snijders, Deborah" sort="Snijders, Deborah" uniqKey="Snijders D" first="Deborah" last="Snijders">Deborah Snijders</name><affiliation wicri:level="1"><nlm:affiliation>Department of Women's and Children's Health, University of Padova, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Women's and Children's Health, University of Padova, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Schwerk, Nicolaus" sort="Schwerk, Nicolaus" uniqKey="Schwerk N" first="Nicolaus" last="Schwerk">Nicolaus Schwerk</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatric Pulmonology and Pediatric Lung Transplantation, Hannover Medical School, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatric Pulmonology and Pediatric Lung Transplantation, Hannover Medical School, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Griese, Matthias" sort="Griese, Matthias" uniqKey="Griese M" first="Matthias" last="Griese">Matthias Griese</name><affiliation wicri:level="3"><nlm:affiliation>Lung Research Group, Children's Hospital of Ludwig, Maximilians University, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Lung Research Group, Children's Hospital of Ludwig, Maximilians University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author></analytic><series><title level="j">Thorax</title><idno type="eISSN">1468-3296</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bronchoalveolar Lavage (methods)</term><term>Bronchoscopy (methods)</term><term>Child</term><term>Clinical Protocols</term><term>Diagnosis, Differential</term><term>Disease Management</term><term>Europe (epidemiology)</term><term>Humans</term><term>Lung Diseases, Interstitial (diagnosis)</term><term>Lung Diseases, Interstitial (epidemiology)</term><term>Lung Diseases, Interstitial (therapy)</term><term>Morbidity</term><term>Tomography, X-Ray Computed (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Bronchoscopie ()</term><term>Diagnostic différentiel</term><term>Enfant</term><term>Europe (épidémiologie)</term><term>Humains</term><term>Lavage bronchoalvéolaire ()</term><term>Morbidité</term><term>Pneumopathies interstitielles ()</term><term>Pneumopathies interstitielles (diagnostic)</term><term>Pneumopathies interstitielles (épidémiologie)</term><term>Prise en charge de la maladie</term><term>Protocoles cliniques</term><term>Tomodensitométrie ()</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Europe</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lung Diseases, Interstitial</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Pneumopathies interstitielles</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Lung Diseases, Interstitial</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Bronchoalveolar Lavage</term><term>Bronchoscopy</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Lung Diseases, Interstitial</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Europe</term><term>Pneumopathies interstitielles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Clinical Protocols</term><term>Diagnosis, Differential</term><term>Disease Management</term><term>Humans</term><term>Morbidity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Bronchoscopie</term><term>Diagnostic différentiel</term><term>Enfant</term><term>Humains</term><term>Lavage bronchoalvéolaire</term><term>Morbidité</term><term>Pneumopathies interstitielles</term><term>Prise en charge de la maladie</term><term>Protocoles cliniques</term><term>Tomodensitométrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Interstitial lung disease in children (chILD) is rare, and most centres will only see a few cases/year. There are numerous possible underlying diagnoses, with specific and non-specific treatment possibilities. The chILD-EU collaboration has brought together centres from across Europe to advance understanding of these considerations, and as part of this process, has created standard operating procedures and protocols for the investigation of chILD. Where established consensus documents exist already, for example, for the performance of bronchoalveolar lavage and processing of lung biopsies, these have been adopted. This manuscript reports our proposals for a staged investigation of chILD, starting from when the condition is suspected to defining the diagnosis, using pathways dependent on the clinical condition and the degree of illness of the child. These include the performance of genetic testing, echocardiography, high-resolution CT, bronchoscopy when appropriate and the definitive investigation of lung biopsy, in order to establish a precise diagnosis. Since no randomised controlled trials of treatment have ever been performed, we also report a Delphi consensus process to try to harmonise treatment protocols such as the use of intravenous and oral corticosteroids, and add-on therapies such as hydroxychloroquine and azithromycin. The aim is not to dictate to clinicians when a therapeutic trial should be performed, but to offer the possibility to collaborators of having a unified approach when a decision to treat has been made. </div></front></TEI><affiliations><list><country><li>Allemagne</li><li>France</li><li>Italie</li><li>Royaume-Uni</li><li>Turquie</li></country><region><li>Angleterre</li><li>Basse-Saxe</li><li>Bavière</li><li>District de Haute-Bavière</li><li>Grand Londres</li><li>Écosse</li><li>Île-de-France</li></region><settlement><li>Créteil</li><li>Hanovre</li><li>Londres</li><li>Munich</li><li>Paris</li><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Bush, Andrew" sort="Bush, Andrew" uniqKey="Bush A" first="Andrew" last="Bush">Andrew Bush</name></region><name sortKey="Cunningham, Steve" sort="Cunningham, Steve" uniqKey="Cunningham S" first="Steve" last="Cunningham">Steve Cunningham</name><name sortKey="Nicholson, Andrew G" sort="Nicholson, Andrew G" uniqKey="Nicholson A" first="Andrew G" last="Nicholson">Andrew G. Nicholson</name></country><country name="France"><region name="Île-de-France"><name sortKey="De Blic, Jacques" sort="De Blic, Jacques" uniqKey="De Blic J" first="Jacques" last="De Blic">Jacques De Blic</name></region><name sortKey="Clement, Annick" sort="Clement, Annick" uniqKey="Clement A" first="Annick" last="Clement">Annick Clement</name><name sortKey="Epaud, Ralph" sort="Epaud, Ralph" uniqKey="Epaud R" first="Ralph" last="Epaud">Ralph Epaud</name></country><country name="Italie"><noRegion><name sortKey="Barbato, Angelo" sort="Barbato, Angelo" uniqKey="Barbato A" first="Angelo" last="Barbato">Angelo Barbato</name></noRegion><name sortKey="Snijders, Deborah" sort="Snijders, Deborah" uniqKey="Snijders D" first="Deborah" last="Snijders">Deborah Snijders</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Hengst, Meike" sort="Hengst, Meike" uniqKey="Hengst M" first="Meike" last="Hengst">Meike Hengst</name></region><name sortKey="Griese, Matthias" sort="Griese, Matthias" uniqKey="Griese M" first="Matthias" last="Griese">Matthias Griese</name><name sortKey="Schwerk, Nicolaus" sort="Schwerk, Nicolaus" uniqKey="Schwerk N" first="Nicolaus" last="Schwerk">Nicolaus Schwerk</name><name sortKey="Wetzke, Martin" sort="Wetzke, Martin" uniqKey="Wetzke M" first="Martin" last="Wetzke">Martin Wetzke</name></country><country name="Turquie"><noRegion><name sortKey="Kiper, Nural" sort="Kiper, Nural" uniqKey="Kiper N" first="Nural" last="Kiper">Nural Kiper</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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